Sildenafil Citrate For ED And The Time It Takes To Work


The active ingredient in most erectile dysfunction pills is Sildenafil Citrate. It helps to dilate blood vessels to escalate blood supply to the penile organ. It also smoothens the erectile tissues and muscles. This causes a hard erection, which can last for several hours.

But how long does Sildenafil remain in the body? How much time will it take to give results? When does it exit the system? What influences its efficacy? All these depend on several factors. In the below-given post, we will take you across these pointers.

How Does Sildenafil Citrate Work for ED?

Erection is a result of several changes in the body. When you are sexually aroused, even psychologically, a hard-on happens. But direct stimulation to the penile organ may give a better result. During an erection, the corpus cavernosa fills up with blood as it relaxes. This leads to the stiffness of the phallus.

The corpus cavernosa contains two cylindrical-shaped spongy chambers. If these do not get enough blood supply, the hard-on remains weak. Interference but blood flow happens because of clogged arteries, stress, penile injury, and other factors. This leads to erectile dysfunction.

Sildenafil Citrate widens the blood vessels. As the penile organ easily gets the blood supply, it hardens during arousal. Also, the stiffness can happen anytime you are excited till 4 to 6 hours. In this duration, the medicine remains effective. With a good erection, you can then enjoy intimacy to the fullest.

How Much Time Does It Take for the Pill to Work?

It takes 45 to 60 minutes for the medicines to start working. This is true if Sildenafil is available in oral tablet format. If it is in the form of a soft chewable tablet or oral jelly, then the working time is either similar or lesser. Remember, the pill will not work on its own if there is no arousal for an erection.

You must remain comfortable during intimacy. Sexual stimulation must happen for a hard-on to take place. If a psychological stimulus is not enough, try a physical one as well. It is then the ingredients of the pill that will help to sustain a hard-on. The excitement must stay on for the hard-on to last.

How Long the Effect of Medicine Lasts?

The medication’s effect can last 4 to 6 hours. The duration of the effect depends on several factors. Some of these are your age, body’s metabolism, pill dosage, and other external factors. You can get an erection as many times as you can within this duration.

The frequency of hard-on also depends on how your body metabolizes the medicine. But there is no evidence to show that the tablet can lengthen the time of having intercourse. It has no function to make you last in bed. This depends on your interest in physical activity.

Some people think that after an erection subsides, they will get another soon. But it may take time for a hard-on to happen again. Because after ejaculation, the body does take some time to prepare physically for the next one. So, Sildenafil Citrate here is not to blame if erection delays after orgasm.

After the refractory period, you will get the stiffness of the phallus as desired. But your body has to recover first from the previous encounter. The bioavailability of a 100mg pill when taken with food, has a delay of 2 hours more than regular working time. When taken without food, the concentration of the ingredient in blood happens as soon as in 60 minutes.

When Will Sildenafil Leave Your System?

Sildenafil Citrate takes 2 to 3 hours or more to leave your system. The timing for it depends on your metabolism. Sometimes, the active ingredient of the product can take 5 to 6 hours to finally leave the body. A lower dose will leave the body quicker than a higher dose.

So, if you take a 25mg dose, it will quit your system sooner as compared to a 100mg dose. After using the medication regularly, you will understand the effectiveness of the medicine. It differs from person to person because of their health, and other reasons.

Which Things You Must Keep in Mind?

As understood, Sildenafil Citrate works for a few hours. But this does not mean you will have an erection throughout this duration. The medicine allows the blood to flow freely to the male reproductive organ. For the pill to work faster, try to stimulate and remain excited sexually.

The foreplay will make things easier. If the medicine does not work after 60 minutes, then talk to your doctor the next time about it. But do not take an additional pill, as it can cause severe side effects. Taking too much ED pill can cause priapism. The erection stays on for more than 4 hours and is painful.

Will Sildenafil Work for Women?

Females also face sexual dysfunction such as vaginal dryness, pain during intercourse, lack of libido, etc. Even for them, Sildenafil Citrate can work. But the composition of medicine meant for women is different. They must not take medications that fall under men’s health. Thus, ED tablets are not for them.

They can however look for Female Viagra and alternatives. Such kinds of medicines help women to feel aroused, lubricate the genitals and increase blood flow to erogenous areas. Together, the medication allows females to experience ultimate pleasure in the bed.

Bonus Read: Have complete knowledge about the best female viagra pills.

What Influences the Longevity of Sildenafil Citrate Effect?

How long Sildenafil will work depends on the below-given factors:

Your Health

Certain health issues can affect how long the ED medication takes to work. It also has a say in how much time the effect of the pill will linger. Medical conditions that negatively affect the efficacy of the tablet are diabetes, multiple sclerosis (MS), kidney and liver diseases.

Other nervous system disorders may also deter the medicine’s activity. Cardiovascular problems such as atherosclerosis also do the same. Here, fat gets deposited in the blood vessels. This reduces the benefit of the product. Your body’s metabolism also impacts how much time the pill will work.


Metabolism slows down as you grow older. Thus, Sildenafil Citrate will last for a longer time as you age. So, for those who are above 50 to 60 years of age, the working of the pill is for more time.


Those who do not exercise often, lead a sedentary life, are more prone to ED. The medicine will delay affecting people who are obese. Also, if you drink alcohol heavily and smoke, then the arteries will clog. This will interfere with blood circulation. So, the impact of the pill is also lesser.


If you take Sildenafil Citrate on an empty stomach, it works faster. If you take the same after a large meal or post eating high-fat food, then the medicine will delay giving results. If you wish to eat something before the medication, stick to a simple and light meal.

Medicines You Take

Certain medicines and products may interact with Sildenafil Citrate. These include HIV medicines, erythromycin, other nitrate medications, clarithromycin, ciprofloxacin, and a few others.

Mental State

How well you respond to the medication depends on your psychological state. Feeling stressed, depressed, nervous, or anxious will interfere with sexual arousal. Thus, the medicine will take more time to work in the body. Without stimulation, an erection usually does not take place.


The dosing amount of the ED pill decides the stay time in the body. For instance, a 50mg pill’s effect compared to a 25mg pill is more. The impact of the 100mg pill is higher than both mentioned. However, how much dose is suitable for you, let a doctor decide that. Do not take a higher dose, if not recommended by a professional.

When Should You Visit a Physician?

Before you take Sildenafil Citrate, have a word with your doctor. If you take any other medicine, inform your physician about it. You must know how much dose is safe to have in 24 hours. If you face any serious side effects like blurred vision, fainting, pain, or ringing in the ears, contact your healthcare provider.

Some products you take may disrupt the action of the ED pill. These can increase or decrease your blood pressure. If the medicine is not working for you, then see for alternatives. Some of these are penile injections, implants, vacuum devices, pelvic floor exercises, therapy for psychological conditions, and others.

Final Words

To treat erectile dysfunction, Sildenafil Citrate is one of the excellent options. It is FDA approved and works in most men. But how well it works for a person, depends on the factors we discussed above. To know how effective this product will be for you, talk to a doctor.

He/she will analyse your health, check the ongoing treatments and medicines, and evaluate the need for the medicine. Then the physician will decide on a suitable dose. You must not overdose. Rather, you should follow the prescribed dose. This will give you the desired result with any odd outcomes.


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