Misoprostol

Misoprostol
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Active Ingredient : Misoprostol

Strengths : 200 MCG

Average Delivery : 10 To 12 Working Days

Expire Date : 10/03/2022

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The intake of a generic drug, Misoprostol happens at a later stage after consumption of Mifeprostine to end a pregnancy. Misoprostol derives from the brand name Cytotec.

Blockage of a pregnancy hormone, Progesterone and widening cervix to stop developing pregnancy parts is possible with consumption of Misoprostol. This widening happens because fetus gets separated from the ruptured lining of the uterus that lacks oxygen and required nutrition.

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Everything you need to know to Buy Misoprostol Online online & How to use it?

Consume Misoprostol containing 800 mcg (200 mcg each of 4 pills) after the Mifepristone pill. Insert Misoprostol pills under the tongue. They should not be chewed, crushed, broken, and swallowed. But they can be consumed with food or milk during the night time to have a proper impact.

What are the dosages and administrations of Misoprostol?

Prescription of Misoprostol to women is for the medical termination of intrauterine pregnancy. The intake of pills is possible up to 9 weeks gestation based on the first day of amenorrhea or last menstrual period. For this treatment, the doctor considers pregnancy from the first day of amenorrhea in a presumed 28-day cycle, with ovulation occurring at mid-cycle.

Never omit or exceed or alter the dosage without consultation of the doctor. It is essential to determine the duration of pregnancy from menstrual history and by clinical examination. If the period of pregnancy is uncertain, ultra-sonogram (USG) scan is a must. In case of suspicion with ectopic pregnancy, usage of USG eradicates pregnancy.

Remove any intrauterine device (IUD) before using the kit. Pregnancy termination by surgery is the case of Misoprostol failure to cause intrauterine pregnancy termination.

A gynecologist administers Misoprostol after gestational age assessment of the fetus. In case of negative results, the advice might be to diagnose ectopic pregnancies. The gynecologist should also be able to perform the surgical intervention in cases of severe bleeding or incomplete abortion.

Consume Mifepristone 200 mg initially and after three days follow the oral intake of Misoprostol 800 mcg (4 pills of 200 mcg). A trained medical professional administers treatment with Misoprostol, or it can also be self-administered by the woman in case the doctor allows doing so. If the abortion does not occur in 3 hours after administration of Misoprostol, a second dose is likely to administer.

Usually, the patient using Misoprostol should return for a follow-up visit after 7-14 days of administration. The follow up is to confirm that a complete pregnancy termination has occurred with the help of clinical examination or USG scan.

For patients using Misoprostol tablets

  • This medicine is prescribed only by your doctor. The entire treatment only requires three visits to your doctor.
  • At the first visit, a prescription of one Mifepristone tablet is likely to happen. Two days later, on the second visit, you will be prescribed another four pills of Misoprostol. During the third visit after two weeks, your doctor will confirm the status of your pregnancy. The process may include an ultrasound exam (sonogram) for confirmation of abortion.
  • Misoprostol will cause you to bleed and have cramps for about 2 to 4 weeks. Call your doctor if you have little or no vaginal bleeding after consumption of the medicine.
  • It is sometimes necessary to have a surgical abortion to end the pregnancy ultimately. You might need surgery if there is any tissue left in the uterus after treatment with Misoprostol.
  • Tell your doctor if you are using an intrauterine device (IUD). Removal of IUD will take place before using the medicine.

What are the contraindications?

Administration of Misoprostol contraindicated in patients who have:

  • history of Mifepristone and Misoprostol allergy
  • suspected or confirmed an ectopic pregnancy
  • migraine issues
  • IUD in place
  • chronic adrenal failure
  • bleeding disorders
  • anticoagulant, corticosteroid therapies
  • inherited porphyria
  • severe uncontrolled asthma

Above mentioned issues is not a complete list of contraindications, but in case you face any other, talk to your doctor and find suggestions on the other problems.

Misoprostol might turn out to be an issue if a patient has no adequate access to medical facilities. In turn, she needs emergency treatment in case of an incomplete abortion, blood transfusions, and emergency resuscitation.

What are the warnings and precautions?

Misoprostol is not a recommendation to patients with renal failure, hepatic failure, and malnutrition. The administration of Misoprostol must be under the supervision of a certified gynecologist.

Currently, there are no data on the safety and effectiveness of Misoprostol in women with chronic diseases such as heart disease, hypertension, liver dysfunction, respiratory or kidney disease, insulin-dependent diabetes, severe anemia, or heavy smoking. Women above 35 years of age who smoke need treatment with great caution.

Studies in animals or humans have demonstrated fetal abnormalities, and there is positive evidence of human fetal risk. The survey confirms with a base on adverse reaction data from investigational or marketing experience. Also, there are risks involved in the use of the drug in pregnant women that outweigh potential benefits.

Patients should be well aware of the Misoprostol administration and its effects. They must understand the necessity of the treatment and the importance of doctor visits.

Another pregnancy may occur following the termination of pregnancy. So, contraception must be initiated soon after using the Misoprostol before the woman resumes sexual intercourse. Please note that clinical examination is imperative to confirm the complete pregnancy termination after the treatment. In some women, a decrease in hemoglobin concentration, hematocrit, and red blood cell count may occur for those who bleed heavily.

Comments on using Misoprostol

  • The doctor provides pain medications, which indeed are to be appropriately eaten up.
  • Patients with Rh(D) contrary and unsensitized: Rh(D)-immune globulin needs initiation within 72 hours of initial dose administration.
  • Revisit to the doctor is highly recommended within 7 to 14 days to ensure complete expulsion has occurred.
  • If treatment fails, patients may opt for expectant management or suction curettage.

What are the drug interactions?

No specific drug or food interactions with Misoprostol aren’t studied. However, there is a possibility that certain drugs and substances such as ketoconazole, itraconazole, erythromycin, and grapefruit could inhibit the metabolism of Misoprostol. Also, dexamethasone, rifampicin, and certain anticonvulsants may induce Misoprostol metabolism.

Misoprostol, on the other hand, has not been found to interfere with the effects of aspirin. It does not exert clinical impact on the absorption and antiplatelet effects of aspirin. Drug interaction studies between Misoprostol and several NSAIDs had no clinical implications for ibuprofen, diclofenac, piroxicam, aspirin, naproxen, or indomethacin.

Avoid Antacids continuing magnesium during treatment with Misoprostol as this may worsen diarrhea if it already exists.

There are restrictions on the usage of certain medicines to be used together. But, in other cases, two different drugs may be used together even if an interaction might occur. In either of the cases, your doctor may want to change the dose, or other precautions may be necessary.

You must report your doctor the intake of all the medicines that you have been using. Below is the mentioned list of medications that you might be consuming for one or the other reasons. However, the following interactions are just selected based on their potential significance and are not necessarily all-inclusive. There might be a few different combos’ of intake you might follow as prescribed by your doctor.

Thirteen drugs interact with Misoprostol and are categorized based on the severity. Below is the complete list of interactions of drugs:

  • dinoprostone topical- primary drug interaction
  • magnesium carbonate- moderate drug interaction
  • magnesium hydroxide- moderate drug interaction
  • magaldrate- moderate drug interaction
  • magnesium oxide- moderate drug interaction
  • quinapril- moderate drug interaction
  • aluminum carbonate- minor drug interaction
  • aluminum hydroxide- small drug interaction
  • calcium carbonate- minor drug interaction
  • dihydroxy aluminum sodium carbonate- minor drug interaction
  • sodium bicarbonate- minor drug interaction
  • naproxen- minor drug interaction
  • sodium citrate- small drug interaction

What are the side effects?

Misoprostol might commonly induce abdominal or stomach pain, diarrhea. There are few other effects such as vaginal bleeding, painful menstruation, and cramps that occur rarely. Many women who receive Misoprostol, report a side effect. Others say more than one such reaction.

Women sometimes experience a few side effects that are less common, such as:

  • acid or sour stomach
  • belching
  • excess air or gas in the stomach and intestines
  • heartburn, indigestion, passing gas
  • stomach discomfort or upset

What is the case of overdose?

Intolerance studies report no severe side effects where the administration of Misoprostol in a single dose is higher than threefold of that advised for pregnancy termination. In case of accidental massive ingestion, one may experience signs of adrenal failure. In the case of acute intoxication, one may require special treatment, including dexamethasone administration.

The toxic dose of Misoprostol in humans is not determined yet. However, a total daily dose of 1600 mcg has been tolerated well, with only symptoms of gastrointestinal discomfort. Signs of an overdose include tremor, sedation, convulsions, breathlessness, abdominal pain, diarrhea, fever, hypotension, and bradycardia. In cases of overdose, seek medical attention right away.

Where should I store Misoprostol?

Misoprostol needs to be stored at room temperature, preferably away from moisture, heat, and sunlight. Keep the container tightly closed with the cap provided. Always maintain a distance away from children and pets. Read all patient information, medication guide, and instructions provided to you. Follow the guidelines as mentioned on the pack if you have any questions related to storing Misoprostol.

Buy Misoprostol Online: FAQs

Now that you are done reading all the necessary information; here are some of the most frequently asked questions that patients have on how to buy Misoprostol online & use it to get the best results.

Will I vomit after taking Misoprostol pill?

Some women do feel nauseating after taking the pill. Check with the doctor if you think nauseated or vomit; you may need an antiemetic drug to stop vomiting.

What happens if I skip/miss a dose?

Take the skipped/missed dose as soon as possible. Make sure you skip the missed dose if it is almost near to the next scheduled dose. Do not take extra medicine to compensate or to make up the missed dose. If you miss doses or forget to take Misoprostol for several days, check with your doctor before starting the consumption of drug again.

What to do if I accidentally swallowed Misoprostol pills?

Misoprostol pills are safe and usually effective if swallowed. However, there may be some gastrointestinal effects when the intake of tablets directly enters the stomach.

Does Misoprostol affect my fertility?

Misoprostol does not have any long-term impact on your health or fertility. Most women will ovulate within a few weeks and will resume their menstruation within four weeks after pregnancy termination. So, a woman can become pregnant within weeks after stopping the use of Misoprostol.

When can I resume sexual intercourse after the treatment?

Generally, women are advised not to participate in sexual intercourse for at least one week after the treatment with Misoprostol.

Will I have any psychological disturbances after treatment?

It is unlikely so. Early medical termination of pregnancy is often associated with an increase in psychological disturbances such as depression and anxiety. The risk of mental health problems is less with Misoprostol treatment.

Is it safe to Buy Misoprostol Online online?

Yes, you can Buy Misoprostol Online securely and in a discreet at SecurePharmaOnline (SPO).  Apart from Soma, SPO deals in a variety of Generic drugs that are clinically proven and cost-effective.  Also, SPO ensures easy availability, authenticity, affordability, complete safety and privacy, and speedy delivery.

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