Best Natural PDE5 Inhibitors That Can Help With Erectile Dysfunction


This article throws light on the best natural PDE5 inhibitors available.

Phosphodiesterase type 5 (PDE5) inhibitors are a kind of vasodilator that helps in the treatment of erectile dysfunction. The relaxation of smooth muscle cells inside the vessel walls causes vasodilating drugs to widen the blood vessels.

Guess what? PDE5 was discovered by mistake as a side effect of a possible treatment for angina and hypertension.

The parasympathetic nervous system is stimulated during an erection. The brain is prompted to release nitric oxide and cyclic GMP as a result of this process.

Nitrous oxide and cGMP aid in muscle relaxation and increased blood flow in the penis. PDE5, on the other hand, breaks down cGMP and prevents an erection.

PDE5 inhibitors function by preventing cGMP-specific PDE5 from degrading cyclic GMP in the smooth muscle cells that line the blood vessels that supply different tissues.

Is it Safe to Take Type 5 Inhibitors?

PDE5 inhibitors, both natural and lab-made, when taken as directed are absolutely safe. Even in patients with a history of cardiovascular disease, all type 5 inhibitors are well tolerated. According to research, these inhibitors may be beneficial in specific clinical groups, such as those with prostate cancer, diabetes, and cardiovascular disease.

In addition, PDE5 therapy increases scores on the International Index of Erectile Function, a multidimensional instrument for measuring male sexual function.

Natural PDE5 Inhibitors for ED

While a number of laboratory-made PDE5 inhibitors like Viagra and Cialis are available in the market, some people also swear by natural and herbal remedies. Along with ED, PDE5 inhibitors can also help treat diabetes, heart disease, cancer, and possibly cognitive disorders, according to research. Here we list down the 4 most popular natural PDE5 inhibitors.

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1. Horny Goat Weed (Epimedium)

Several studies conducted on cells in laboratories have found evidence of horny goat weed’s beneficial properties. According to research, it may have properties that help to strengthen bones, protect nerves, and support the immune system.

The herb has been used in alternative medicine to treat anything from hay fever to nerve pain, exhaustion, osteoporosis, and erectile dysfunction.

The chemicals present in horny goat weed can help increase blood flow, resulting in an improvement in sexual function. It also includes phytoestrogens, which are chemicals that behave similarly to estrogen in women.

Studies have also found several other benefits, which include:

  • Anti-cancer properties
  • Preventing bone loss after menopause
  • Anti-HIV activity
  • Reversal of multidrug resistance in tumour cells
  • Helps with Atherosclerosis
  • Radio sensitizing effects

Side Effects

When taken as directed, horny goat weed extract is possibly safe.

A phytoestrogen-rich extract of horny goat cannabis can be taken by mouth for up to two years. A different horny goat plant extract containing icariin is also safe if taken orally for up to 6 months.

However, when used for an extended period of time or in high doses, certain forms of horny goat weed can possibly be unsafe. Long-term use of these other types of horny goat weed can result in dizziness, dry mouth, vomiting, thirst, and nosebleed. Large doses of horny goat weed can cause severe breathing problems and spasms.

2. Thai Ginger (Kaempferia Parviflora Rootstalk)

PDE5 inhibitors can be found in Thai ginger, also known as black ginger. Thai ginger can increase handgrip strength and enhance sexual drive, according to scientific evidence. Black ginger is darker in colour than typical ginger. On the outside, the two gingers are identical, but black ginger has a deep purple interior.

The black ginger extract comes in powdered, liquid, and encapsulated forms. The powdered version is available as a food product.

Thai ginger is often used for the following reasons:

  • Improved physical performance
  • Weight-loss assistance
  • Upregulation of SIRT-1
  • Antioxidant
  • Male sexual dysfunction; aphrodisiac
  • Cognitive support
  • Antiviral/effective vs. influenzas

It is best to refrain from taking Thai ginseng without first consulting a doctor or pharmacist if you are taking erectile dysfunction (ED) medications like Viagra, Levitra, or Cialis.

Side Effects

When consumed by mouth, ginger is mostly safe. Heartburn, burping, diarrhoea, and general stomach pain are all mild side effects of ginger. Although, if overdosed, it may lead to central nervous system depression.

Eating ginger has been linked to increased menstrual bleeding in some women. Ginger may also help prevent blood clots. If you have undergone surgery or are going to undergo one, avoiding Black Ginger is best as it may otherwise result in extra bleeding. It is suggested to stop using ginger at least two weeks before a planned surgery.

3. Pomegranate

Pomegranates, which are high in antioxidants, have been shown to have a number of health benefits, including a lower risk of heart disease and high blood pressure.

Pomegranate also inhibits the development of estrogen. This is extremely important for testosterone levels. Too much estrogen can result in lower libido, erectile dysfunction, and bone deterioration. All in all, pomegranate stimulates the production of testosterone, which enhances male libido.

Additionally, pomegranate juice increases blood flow which further helps in erectile dysfunction by increasing blood flow to the penis during sexual intercourse.

Side Effects

While pomegranate has a bunch of health benefits, too much of it can be harmful. The following are some of the potential pomegranate side effects:

Pomegranate has the ability to lower blood sugar levels. As a result, people who take diabetes medication should exercise caution while drinking pomegranate juice. It’s possible that combining it with medicine will result in low blood sugar.

Pomegranate consumption has some drawbacks, including allergies. Hence, people with a history of food allergies should exercise caution when consuming pomegranates. When ingested orally in large amounts, the root, stem, or peel of the pomegranate is unsafe.

4. Korean Red Ginseng

Korean red ginseng has been used to improve male sexual function for a long time, but few studies have attempted to prove its efficacy. The herb was found to help relieve erectile dysfunction symptoms and bring “enhanced penile tip rigidity,” as was found in a study.

Increased alertness has been linked to Korean red ginseng, which can help with erectile dysfunction. Red ginseng is also believed to stimulate nitric oxide synthesis, but experts aren’t sure exactly how it works.

Side Effects

Korean red ginseng use has been linked to a number of adverse side effects, including:

  • Nausea
  • Headaches
  • Agitation
  • An increase or decrease in blood pressure

Although ginseng is generally considered safe when taken for short periods of time, serious allergy issues may arise in certain individuals. In such instances, one should immediately contact the doctor.


PDE5 inhibitors are used to treat ED and a variety of other diseases, including diabetes and cancer. These inhibitors suppress the enzyme PDE5, which is found in the walls of blood vessels. Thereby the blood vessels are relaxed, allowing more blood to flow to specific parts of the body. As a result of this effect, they may aid in the treatment of erectile dysfunction and pulmonary hypertension.

Its other possible benefits in cognitive health are also being investigated. Although some people may experience side effects, PDE5 is usually well tolerated. If you have an existing condition or are taking drugs, it is advised to consult your doctor before taking PDE5 supplements.

Despite the positive results of studies relating to the consumption of these herbs and supplements, it is best to consult your doctor before beginning any supplementation. If taken with synthetic ED pills, these natural PDE5 inhibitors can cause side effects. For instance, PDE5 inhibitors should not be combined with nitrate medications because the combination can cause a steep drop in blood pressure levels, which can be fatal.


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